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KMID : 0603820150210020051
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Journal of Experimental & Biomedical Science
2015 Volume.21 No. 2 p.51 ~ p.59
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Humanized (SCID) Mice as a Model to Study human Leukemia
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Lee Ji-Yoon
Kim Dong-hyun
Kim Hee-Je
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Abstract
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A humanized mice (hu-mice) model is extremely valuable to verify human cell activity in vivo condition and is regarded as an important tool in examining multimodal therapies and drug screening in tumor biology. Moreover, hu-mice models that simply received human CD34+ blood cells and tissue transplants are also overwhelmingly useful in immunology and stem cell biology. Because generated hu-mice harboring a human immune system have displayed phenotype of human CD45+ hematopoietic cells and when played partly with functional immune network, it could be used to evaluate human cell properties in vivo. Although the hu-mice model does not completely recapitulate human condition, it is a key methodological factor in studying human hematological malignancies with impaired immune cells. Also, an advanced humanized leukemic mice (hu-leukemic-mice) model has been developed by improving immunodeficient mice. In this review, we briefly described the history of development on immunodeficient SCID strain mice for hu-and hu-leukemic-mice model for immunologic and tumor microenviromental study while inferring the potential benefits of hu-leukemic-mice in cancer biology.
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KEYWORD
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Humanized, Mice model, Acute myeloid leukemia
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